Methyl L-tert-leucinate hydrochloride → HCID 178445946, compound

Participants

Reaction Steps

50 mg (0.12) of 7-(4-tert-Butyl-cyclohexyloxy)-1-cyclopentylmethyl-isoquinoline-3-carboxylic acid (Example 430) was reacted with (2S)-amino-3,3-dimethyl-butyric acid methyl ester HCL (24.7 mg, 0.14 mmol) as described in general procedure A. The resulting ester was hydrolyzed by sonication at rt for 3 h and then usual work up as described in general procedure C afforded 54.3 mg of the title compound as a white solid.

Provenance & Evidence