HRID1984850

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID422659

methyl 2-(benzylamino)acetate

C10H13NO2

结构：CC(C)(C)c1ccc(Oc2ccc3cc(C(=O)Cl)nc(CC4CCCC4)c3c2)cc1

HCID86597133

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)c1ccc(Oc2ccc3cc(C(=O)N(CC(=O)O)Cc4ccccc4)nc(CC4CCCC4)c3c2)cc1

HCID57718021

未命名化合物

收率 70.8%

PROCEDURE

实验过程

The title compound (39 mg) was prepared following the same procedures that was described for example 432 from benzyl glycine methyl ester (17.9 mg, 0.1 mmol) and 7-(4-tert-butyl-phenoxy)-1-cyclopentylmethyl-isoquinoline-3-carbonyl chloride (46 mg, 0.1 mmol).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-73f7b15366cc4436bda292f56614272b
来源数据集: uspto-grants-2009_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07544699B2
来源说明: uspto-grants-2009_06

反应 SMILES

C[O:2][C:3](=[O:13])[CH2:4][NH:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[C:14]([C:18]1[CH:43]=[CH:42][C:21]([O:22][C:23]2[CH:32]=[C:31]3[C:26]([CH:27]=[C:28]([C:39](Cl)=[O:40])[N:29]=[C:30]3[CH2:33][CH:34]3[CH2:38][CH2:37][CH2:36][CH2:35]3)=[CH:25][CH:24]=2)=[CH:20][CH:19]=1)([CH3:17])([CH3:16])[CH3:15]>>[CH2:6]([N:5]([CH2:4][C:3]([OH:2])=[O:13])[C:39]([C:28]1[N:29]=[C:30]([CH2:33][CH:34]2[CH2:35][CH2:36][CH2:37][CH2:38]2)[C:31]2[C:26]([CH:27]=1)=[CH:25][CH:24]=[C:23]([O:22][C:21]1[CH:42]=[CH:43][C:18]([C:14]([CH3:16])([CH3:17])[CH3:15])=[CH:19][CH:20]=1)[CH:32]=2)=[O:40])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1