HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 68868389, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | HCID 68871420 | HCID 68871420 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 68868389 | HCID 68868389 | 118.2% |
Reaction Steps
A solution of 7-(4-tert-butyl-cyclohexylcarbamoyl)-1-cyclopentylmethyl-isoquinoline-3-carboxylic acid methyl ester (57 mg, 0.126 mmol) in THF:MeOH was treated with an aq. solution of LiOH (26 mg, 0.632 mmol) via the general procedure I to give 65 mg of 7-(4-tert-butyl-cyclohexylcarbamoyl)-1-cyclopentylmethyl-isoquinoline-3-carboxylic acid. This was used directly for the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07544699B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-876a81464692484fb23a18bf8766183b |
| Source note | uspto-grants-2009_06 |