Dichloromethane → HCID 178478819, compound

Participants

Reaction Steps

A solution of trans-[({4-[(4-bromo-2-trifluoromethoxy-benzenesulfonylamino)-methyl]-cyclohexylmethyl}-amino)-tert-butoxycarbonylamino-methyl]-carbamic acid tert-butyl ester (53 mg, 0.077 mmol) in 50% TFA in CH2Cl2 (2 mL) was stirred at ambient temperature for 3 hr and the reaction mixture was concentrated. To the residue was added a solution of 1 M HCl in Et2O (0.5 mL) and the mixture was concentrated to give trans-4-Bromo-N-(4-guanidinomethyl-cyclohexylmethyl)-2-trifluoromethoxy-benzenesulfonamide dihydrochloride as a white solid (29 mg, 68%).

Provenance & Evidence