Dichloromethane → HCID 178479556, compound

Participants

Reaction Steps

To a solution of cis-(4-carbamoyl-cyclohexyl)-carbamic acid tert-butyl ester (62 g, 256 mmol) in CH2Cl2 (250 mL) was added TFA (250 mL) and the mixture was stirred at ambient temperature for 1 hr. The mixture was concentrated and 2 M HCl in Et2O (150 mL) was added to give a white precipitate. The mixture was concentrated to give cis-4-amino-cyclohexanecarboxylic acid amide hydrochloride (45 g, 98%) as a white solid.

Provenance & Evidence