Triethylamine → HCID 178453922, compound

Participants

Reaction Steps

To a solution of cis-[4-(2-amino-ethyl)-cyclohexyl]-carbamic acid tert-butyl ester (4.84 g, 20 mmol) in CH2Cl2 (50 mL) and triethylamine (3.06 mL, 22 mmol) was added benzyl chloroformate (3.13 mL, 22 mmol) and the mixture was stirred for 4 hr. The resulting mixture was washed with water, 1 M aqueous HCl, dried over Na2SO4, filtered and concentrated. The residue was purified by column chromatography (silica gel, CH2Cl2 to 10% MeOH in CH2Cl2) to give cis-[4-(2-benzyloxycarbonylamino-ethyl)-cyclohexyl]-carbamic acid tert-butyl ester (5.46 g, 73%) as a colorless oil.

Provenance & Evidence