HCID 178453922, compound → HCID 178511524, compound

Participants

Reaction Steps

A solution of cis-[4-(2-benzyloxycarbonylamino-ethyl)-cyclohexyl]-carbamic acid tert-butyl ester (5.26 g, 14 mmol) in 50% TFA in CH2Cl2 (60 mL) was stirred at ambient temperature for 1 hr. The mixture was concentrated and the residue was diluted with saturated aqueous NaHCO3. The aqueous layer was extracted with CH2Cl2 (therr times). The organic layer was dried over Na2SO4 and concentrated to give cis-[2-(4-amino-cyclohexyl)-ethyl]-carbamic acid benzyl ester (3.5 g, 91%) as a colorless oil.

Provenance & Evidence