HCID 178483073, compound → HCID 178483070, compound

Participants

Reaction Steps

A solution of cis-{4-[(4-dimethylamino-quinazolin-2-ylamino)-methyl]-cyclohexyl}-carbamic acid tert-butyl ester (1.2 g, 3 mmol) in 50% TFA in CH2Cl2 (20 mL) was stirred at ambient temperature. After 30 minutes, the mixture was concentrated and the residue was diluted with 1 M aqueous sodium hydroxide. The aqueous layer was extracted with CH2Cl2 (twice). The combined organic layer was dried over Na2SO4, filtered and concentrated to give cis-N2-(4-amino-cyclohexylmethyl)-N4,N4-dimethyl-quinazoline-2,4-diamine (0.88 g, 98%) as a white solid.

Provenance & Evidence