2-Chloro-N,N-dimethylquinazolin-4-amine → HCID 178483097, compound

Participants

Reaction Steps

To a solution of trans-N-(4-amino-cyclohexyl)-4-bromo-2-trifluoromethoxy-benzenesulfonamide (100 mg, 0.24 mmol) in 2-propanol (0.5 mL) was added (2-chloro-quinazolin-4-yl)-dimethly-amine obtained in step B of example 1 (54.7 mg, 0.26 mmol). The mixture was heated using a Smith Microwave Synthesizer at 170° C. for 15 min. The mixture was concentrated and the residue was purified by chromatography (2% to 4% 2 M NH3/MeOH in CH2Cl2) to give trans-4-bromo-N-[4-(4-dimethlyamino-quinazolin-2-ylamino)-cyclohexyl]-2-trifluoromethoxy-benzenesulfonamide (42 mg, 0.71 mmol, 30%) as a white solid.

Provenance & Evidence