6-Bromo-2-naphthoyl chloride → HCID 11338860, compound

HRID 1984971Notes

Reaction equation

HRID 1984971 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([C:12](Cl)=[O:13])[CH:6]=[CH:5]2.[NH2:15][C:16]1[CH:25]=[C:24]2[C:19]([CH2:20][CH:21]([CH2:26][OH:27])[CH2:22][NH:23]2)=[CH:18][CH:17]=1>>[OH:27][CH2:26][CH:21]1[CH2:20][C:19]2[C:24](=[CH:25][C:16]([NH:15][C:12]([C:7]3[CH:6]=[CH:5][C:4]4[C:9](=[CH:10][CH:11]=[C:2]([Br:1])[CH:3]=4)[CH:8]=3)=[O:13])=[CH:17][CH:18]=2)[NH:23][CH2:22]1

Participants

3

Reactant 2

HCID 218796066-Bromo-2-naphthoyl chlorideHCID 57808081HCID 57808081, compound

Product 1

HCID 11338860HCID 11338860, compound

Procedure

This material was prepared analogous to the procedure described for Example 1(c). 6-Bromo-naphthalene-2-carbonyl chloride, Example 2(a), (258 mg, 0.96 mmol) reacted with (7-amino-1,2,3,4-tetrahydro-quinolin-3-yl)-methanol (171 mg, 0.96 mmol, prepared according to the procedure described in WO03049702) to give the title compound as an light-brown amorphous solid. MS (ESI, pos. ion) m/z: 413 (M+1).

Workup

  1. customThis material was prepared analogous to the procedure
  2. customprepared

Sources & evidence

ORD record
ord-35d5a795317c42498a15108fbb9a0f54
Source dataset
uspto-grants-2009_06
Patent number
US07544803B2

Reaction notes

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