7-Aminoquinoline → HCID 11300982, compound

HRID 1984973Notes

Reaction equation

HRID 1984973 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[C:11](Cl)=[O:12].[NH2:14][C:15]1[CH:24]=[C:23]2[C:18]([CH:19]=[CH:20][CH:21]=[N:22]2)=[CH:17][CH:16]=1>>[N:22]1[C:23]2[C:18](=[CH:17][CH:16]=[C:15]([NH:14][C:11]([C:2]3[CH:3]=[CH:4][C:5]4[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=4)[CH:1]=3)=[O:12])[CH:24]=2)[CH:19]=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 113777-AminoquinolineHCID 752462-Naphthoyl chloride

Product 1

HCID 11300982HCID 11300982, compound

Procedure

This material was prepared analogous to the procedure described for Example 1(c). 2-Naphthoyl chloride (200 mg, 1 mmol, Aldrich) reacted with 7-amino-quinoline (102 mg, 0.95 mmol, prepared according to the procedure described in WO03099284) to give the title compound as an off-white amorphous solid. MS (ESI, pos. ion) m/z: 299 (M+1).

Workup

  1. customThis material was prepared analogous to the procedure
  2. customprepared

Sources & evidence

ORD record
ord-3ed5e6156ff449368bcedcc6ad8db3e1
Source dataset
uspto-grants-2009_06
Patent number
US07544803B2

Reaction notes

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