1-Isopropylpiperazine → HCID 11362283, compound

HRID 1984980Notes

Reaction equation

[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([NH:11][C:12]([C:14]3[CH:23]=[CH:22][C:21]4[C:16](=[CH:17][CH:18]=[C:19](Br)[CH:20]=4)[CH:15]=3)=[O:13])[CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[CH:25]([N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1)([CH3:27])[CH3:26]>>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([NH:11][C:12]([C:14]3[CH:23]=[CH:22][C:21]4[C:16](=[CH:17][CH:18]=[C:19]([N:31]5[CH2:32][CH2:33][N:28]([CH:25]([CH3:27])[CH3:26])[CH2:29][CH2:30]5)[CH:20]=4)[CH:15]=3)=[O:13])[CH:9]=2)[CH:4]=[CH:3][CH:2]=1

Participants

Reactant 2

HCID 780131-Isopropylpiperazine

HCID 11337876HCID 11337876, compound

Product 1

HCID 11362283HCID 11362283, compound

Procedure

This material was prepared analogous to the procedure described for Example 33. 6-Bromo-naphthalene-2-carboxylic acid quinolin-7-ylamide, Example 32(b), (116 mg, 0.31 mmol) reacted with 1-isopropylpiperazine (315 mg, 2.46 mmol, Aldrich) to give the title compound as a yellow amorphous solid. MS (ESI, pos. ion) m/z: 426 (M+1).

Workup

customThis material was prepared analogous to the procedure

Sources & evidence

ORD record: ord-b85f23d2fc124bfaab131904fcc1ac85
Source dataset: uspto-grants-2009_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07544803B2

Reaction notes

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