3-Pyridinylboronic acid → HCID 11451652, compound

HRID 1984981Notes

Reaction equation

HRID 1984981 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([NH:11][C:12]([C:14]3[CH:23]=[CH:22][C:21]4[C:16](=[CH:17][CH:18]=[C:19](Br)[CH:20]=4)[CH:15]=3)=[O:13])[CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[N:25]1[CH:30]=[CH:29][CH:28]=[C:27](B(O)O)[CH:26]=1>>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([NH:11][C:12]([C:14]3[CH:23]=[CH:22][C:21]4[C:16](=[CH:17][CH:18]=[C:19]([C:27]5[CH:26]=[N:25][CH:30]=[CH:29][CH:28]=5)[CH:20]=4)[CH:15]=3)=[O:13])[CH:9]=2)[CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 27343783-Pyridinylboronic acidHCID 11337876HCID 11337876, compound

Product 1

HCID 11451652HCID 11451652, compound

Procedure

This material was prepared analogous to the procedure described for Example 1 (a). 6-Bromo-naphthalene-2-carboxylic acid quinolin-7-ylamide, Example 32(b), (67 mg, 0.18 mmol) reacted with 3-pyridine boronic acid (24 mg, 0.2 mmol, Fluorochem) to give the title compound as a brown amorphous solid. MS (ESI, pos. ion) m/z: 376 (M+1).

Workup

  1. customThis material was prepared analogous to the procedure

Sources & evidence

ORD record
ord-491bfba4b7954cebaa6d952a08b1e947
Source dataset
uspto-grants-2009_06
Patent number
US07544803B2

Reaction notes

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