(R)-(+)-3-Chlorostyrene oxide → HCID 68901479, compound

Participants

Reaction Steps

A mixture of 10 ml of toluene, 1.92 g of (1R,3R)-3-(3-hydroxyphenyl)cyclohexylamine and 1.55 g of (R)-3-chlorostyrene oxide was heated under reflux for 4 hours. The reaction liquid was cooled to room temperature, a seed crystal was inoculated into it, and stirred as such for 30 minutes. The precipitated crystal was taken out through filtration, and then dried under aeration at 50° C. for 2.5 hours to obtain 2.42 g of the entitled compound.

Provenance & Evidence