HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloropyridine-5-boronic acid → [1-(6-Chloro-pyridin-3-yl)-5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-(4,4-difluoro-piperidin-1-yl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloropyridine-5-boronic acid | HCID 3845034 | — |
| Reactant | (4,4-Difluoropiperidin-1-yl)[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]methanone | HCID 11603838 | — |
| Product | [1-(6-Chloro-pyridin-3-yl)-5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-(4,4-difluoro-piperidin-1-yl)-methanone | HCID 16739441 | — |
Reaction Steps
In analogy to the procedure described for the synthesis of example 6, the title compound was synthesized from (4,4-difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone (intermediate 1) and 2-chloropyridine-5-boronic acid. The title compound was obtained in 36% yield as orange foam. MS (m/e): 517.3 (MH+, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745479B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-25435b5868bc4dfab1190a54d322e8f7 |
| Source note | uspto-grants-2010_06 |