Toluene-4-sulfonic acid 2-[1-(4-methoxy-benzyl)-3-methyl-2-oxo-imidazolidin-4-yl]-ethyl ester → 2-(4-{2-[1-(4-Methoxy-benzyl)-3-methyl-2-oxo-imidazolidin-4-yl]-ethoxy}-3-propyl-phenoxy)-2-methyl-propionic acid ethyl ester

HRID 1985119Notes

Reaction equation

HRID 1985119 reaction equation
[CH3:1][O:2][C:3]1[CH:29]=[CH:28][C:6]([CH2:7][N:8]2[CH2:12][CH:11]([CH2:13][CH2:14][O:15]S(C3C=CC(C)=CC=3)(=O)=O)[N:10]([CH3:26])[C:9]2=[O:27])=[CH:5][CH:4]=1.[CH2:30]([O:32][C:33](=[O:48])[C:34]([O:37][C:38]1[CH:43]=[CH:42][C:41](O)=[C:40]([CH2:45][CH2:46][CH3:47])[CH:39]=1)([CH3:36])[CH3:35])[CH3:31]>>[CH2:30]([O:32][C:33](=[O:48])[C:34]([O:37][C:38]1[CH:43]=[CH:42][C:41]([O:15][CH2:14][CH2:13][CH:11]2[CH2:12][N:8]([CH2:7][C:6]3[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:29][CH:28]=3)[C:9](=[O:27])[N:10]2[CH3:26])=[C:40]([CH2:45][CH2:46][CH3:47])[CH:39]=1)([CH3:35])[CH3:36])[CH3:31]

Participants

3

Reactant 2

HCID 57719164Toluene-4-sulfonic acid 2-[1-(4-methoxy-benzyl)-3-methyl-2-oxo-imidazolidin-4-yl]-ethyl esterHCID 687429302-(4-Hydroxy-3-propyl-phenoxy)-2-methyl-propionic acid ethyl ester

Product 1

HCID 688667142-(4-{2-[1-(4-Methoxy-benzyl)-3-methyl-2-oxo-imidazolidin-4-yl]-ethoxy}-3-propyl-phenoxy)-2-methyl-propionic acid ethyl ester

Procedure

The titled compound is prepared, according to the procedure of Example 1, Step A, using toluene-4-sulfonic acid 2-[1-(4-methoxy-benzyl)-3-methyl-2-oxo-imidazolidin-4-yl]-ethyl ester (0.200 g, 0.478 mmole) and 2-(4-hydroxy-3-propyl-phenoxy)-2-methyl-propionic acid ethyl ester (0.140 g, 0.526 mmole) to produce a colorless oil (0.122 g, 50%). Mass [EI+] 513 (M+H)+.

Sources & evidence

ORD record
ord-77f50433312a4ab285bbd0af5fc0a025
Source dataset
uspto-grants-2009_06
Patent number
US07544812B2

Reaction notes

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