Butylboronic Acid → HCID 68867265, compound

HRID 1985124Notes

Reaction equation

[CH2:1]([O:3][C:4](=[O:37])[C:5]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][CH2:17][CH:18]2[CH2:22][N:21]([CH2:23][C:24]3[CH:29]=[CH:28][C:27]([C:30]([F:33])([F:32])[F:31])=[CH:26][CH:25]=3)[C:20](=[O:34])[N:19]2[CH3:35])=[CH:11][C:10]=1I)([CH3:7])[CH3:6])[CH3:2].[CH2:38](B(O)O)[CH2:39][CH2:40][CH3:41]>>[CH2:1]([O:3][C:4](=[O:37])[C:5]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][CH2:17][CH:18]2[CH2:22][N:21]([CH2:23][C:24]3[CH:29]=[CH:28][C:27]([C:30]([F:33])([F:32])[F:31])=[CH:26][CH:25]=3)[C:20](=[O:34])[N:19]2[CH3:35])=[CH:11][C:10]=1[CH2:38][CH2:39][CH2:40][CH3:41])([CH3:7])[CH3:6])[CH3:2]

Participants

Reactant 2

HCID 20479Butylboronic Acid

HCID 68868762HCID 68868762, compound

Product 1

HCID 68867265HCID 68867265, compound

Procedure

The titled compound is prepared, according to the procedure of Example 3, Step B, using 2-(2-Iodo-4-{3-[3-methyl-2-oxo-1-(4-trifluoromethyl-benzyl)-imidazolidin-4-yl]-propyl}-phenoxy)-2-methyl-propionic acid ethyl ester (0.270 g, 0.430 mmole) and n-butyl boronic acid (0.218 g, 0.215 mmole) to produce an oil (0.115 g, 48%). Mass [EI+] 563 (M+H)+.

Sources & evidence

ORD record: ord-f483138c30d640869785bb31833e0bbb
Source dataset: uspto-grants-2009_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07544812B2

Reaction notes

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