HRID1985126

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1ccc(CN2CC(CCOS(=O)(=O)c3ccc(C)cc3)N(C)C2=O)cc1

HCID57719164

未命名化合物

HCID68868250

未命名化合物

PRODUCTS

生成物

结构：COC(=O)C(C)(Cc1ccc(OCCC2CN(Cc3ccc(OC)cc3)C(=O)N2C)cc1)Oc1ccccc1F

HCID68868765

未命名化合物

PROCEDURE

实验过程

The titled compound is prepared, according to the procedure of Example 1, Step A, using toluene-4-sulfonic acid 2-[1-(4-methoxy-benzyl)-3-methyl-2-oxo-imidazolidin-4-yl]-ethyl ester (0.888 g, 2.12 mmole) and 2-(2-Fluoro-phenoxy)-3-(4-hydroxy-phenyl)-2-methyl-propionic acid methylester (0.645 g, 2.12 mmole) to produce an oil (0.95 g, 81%). Mass [EI+] 551 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ad05e126da3841c3a3eed8f07828b380
来源数据集: uspto-grants-2009_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07544812B2
来源说明: uspto-grants-2009_06

反应 SMILES

[CH3:1][O:2][C:3]1[CH:29]=[CH:28][C:6]([CH2:7][N:8]2[CH2:12][CH:11]([CH2:13][CH2:14][O:15]S(C3C=CC(C)=CC=3)(=O)=O)[N:10]([CH3:26])[C:9]2=[O:27])=[CH:5][CH:4]=1.[CH3:30][O:31][C:32](=[O:51])[C:33]([O:43][C:44]1[CH:49]=[CH:48][CH:47]=[CH:46][C:45]=1[F:50])([CH3:42])[CH2:34][C:35]1[CH:40]=[CH:39][C:38](O)=[CH:37][CH:36]=1>>[CH3:30][O:31][C:32](=[O:51])[C:33]([O:43][C:44]1[CH:49]=[CH:48][CH:47]=[CH:46][C:45]=1[F:50])([CH3:42])[CH2:34][C:35]1[CH:40]=[CH:39][C:38]([O:15][CH2:14][CH2:13][CH:11]2[CH2:12][N:8]([CH2:7][C:6]3[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:29][CH:28]=3)[C:9](=[O:27])[N:10]2[CH3:26])=[CH:37][CH:36]=1