Toluene-4-sulfonic acid 2-[1-(4-methoxy-benzyl)-3-methyl-2-oxo-imidazolidin-4-yl]-ethyl ester → 2-(2-Fluoro-phenoxy)-3-(4-{2-[1-(4-methoxy-benzyl)-3-methyl-2-oxo-imidazolidin-4-yl]-ethoxy}-phenyl)-2-methyl-propionic acid methyl ester

HRID 1985126Notes

Reaction equation

HRID 1985126 reaction equation
[CH3:1][O:2][C:3]1[CH:29]=[CH:28][C:6]([CH2:7][N:8]2[CH2:12][CH:11]([CH2:13][CH2:14][O:15]S(C3C=CC(C)=CC=3)(=O)=O)[N:10]([CH3:26])[C:9]2=[O:27])=[CH:5][CH:4]=1.[CH3:30][O:31][C:32](=[O:51])[C:33]([O:43][C:44]1[CH:49]=[CH:48][CH:47]=[CH:46][C:45]=1[F:50])([CH3:42])[CH2:34][C:35]1[CH:40]=[CH:39][C:38](O)=[CH:37][CH:36]=1>>[CH3:30][O:31][C:32](=[O:51])[C:33]([O:43][C:44]1[CH:49]=[CH:48][CH:47]=[CH:46][C:45]=1[F:50])([CH3:42])[CH2:34][C:35]1[CH:40]=[CH:39][C:38]([O:15][CH2:14][CH2:13][CH:11]2[CH2:12][N:8]([CH2:7][C:6]3[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:29][CH:28]=3)[C:9](=[O:27])[N:10]2[CH3:26])=[CH:37][CH:36]=1

Participants

3

Reactant 2

HCID 57719164Toluene-4-sulfonic acid 2-[1-(4-methoxy-benzyl)-3-methyl-2-oxo-imidazolidin-4-yl]-ethyl esterHCID 688682502-(2-Fluoro-phenoxy)-3-(4-hydroxy-phenyl)-2-methyl-propionic acid methylester

Product 1

HCID 688687652-(2-Fluoro-phenoxy)-3-(4-{2-[1-(4-methoxy-benzyl)-3-methyl-2-oxo-imidazolidin-4-yl]-ethoxy}-phenyl)-2-methyl-propionic acid methyl ester

Procedure

The titled compound is prepared, according to the procedure of Example 1, Step A, using toluene-4-sulfonic acid 2-[1-(4-methoxy-benzyl)-3-methyl-2-oxo-imidazolidin-4-yl]-ethyl ester (0.888 g, 2.12 mmole) and 2-(2-Fluoro-phenoxy)-3-(4-hydroxy-phenyl)-2-methyl-propionic acid methylester (0.645 g, 2.12 mmole) to produce an oil (0.95 g, 81%). Mass [EI+] 551 (M+H)+.

Sources & evidence

ORD record
ord-ad05e126da3841c3a3eed8f07828b380
Source dataset
uspto-grants-2009_06
Patent number
US07544812B2

Reaction notes

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