反应详情

Benzyl bromide (0.02 mL, 0.172 mmol, d=1.438) and tetrabutyl ammonium iodide (catalytic amount) are added to a 0° C. suspension of 2-(2-Fluoro-phenoxy)-2-methyl-3-{4-[2-(3-methyl-2-oxo-imidazolidin-4-yl)-ethoxy]-phenyl}-propionic acid ethyl ester (0.051 g, 0.115 mmol) and sodium hydride (0.011 g, 0.287 mmol, 60% suspension on mineral oil), pre-stirred for 1 h at ambient temperature. The reaction mixture is stirred at ambient temperature for 18 h, diluted with ethyl acetate, and washed with 1N HCl, water, and brine. The organic layer is dried and concentrated in vacuo to provide the title compound, which is used in the next step. MS [EI+] 535 (M+H)+.

1. stirringThe reaction mixture is stirred at ambient temperature for 18 h
2. washwashed with 1N HCl, water, and brine
3. customThe organic layer is dried
4. concentrationconcentrated in vacuo