Sodium Hydroxide → 2-Butoxy-3-(4-{2-[1-(3-methoxy-benzyl)-3-methyl-2-oxo-imidazolidin-4-yl]-ethoxy}-phenyl)-2-methyl-propionic acid

HRID 1985155Notes

Reaction equation

HRID 1985155 reaction equation
C([O:3][C:4](=[O:38])[C:5]([O:33][CH2:34][CH2:35][CH2:36][CH3:37])([CH3:32])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][CH:16]2[CH2:20][N:19]([CH2:21][C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([O:28][CH3:29])[CH:23]=3)[C:18](=[O:30])[N:17]2[CH3:31])=[CH:9][CH:8]=1)C.[OH-].[Na+]>C(O)C>[CH2:34]([O:33][C:5]([CH3:32])([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][CH:16]2[CH2:20][N:19]([CH2:21][C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([O:28][CH3:29])[CH:23]=3)[C:18](=[O:30])[N:17]2[CH3:31])=[CH:9][CH:8]=1)[C:4]([OH:38])=[O:3])[CH2:35][CH2:36][CH3:37]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 688700622-Butoxy-3-(4-{2-(1-(3-methoxy-benzyl)-3-methyl-2-oxo-imidazolidin-4-yl]-ethoxy}-phenyl)-2-methyl-propionic acid ethyl ester

Product 1

HCID 102891072-Butoxy-3-(4-{2-[1-(3-methoxy-benzyl)-3-methyl-2-oxo-imidazolidin-4-yl]-ethoxy}-phenyl)-2-methyl-propionic acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 2-Butoxy-3-(4-{2-[1-(3-methoxy-benzyl)-3-methyl-2-oxo-imidazolidin-4-yl]-ethoxy}-phenyl)-2-methyl-propionic acid ethyl ester and 5N NaOH (0.3 mL) in ethanol (3 mL) is refluxed under nitrogen for 1 h, cooled to ambient temperature, and concentrated in vacuo. The residue is diluted with 1N HCl, extracted, dried, concentrated, and purified by LCMS to provide the title compound. 1H NMR (400 MHz, CDCl3): δ 7.22 (t, 1H, J=8.0 Hz), 7.07 (d, 2H, J=8.5 Hz), 6.83-6.79 (m, 3H), 6.72 (d, 2H, J=8.5 Hz), 4.38, 4.30 (ABq, 2H, J=15.1 Hz), 3.95 (t, 2H, J=6.0 Hz), 3.78 (s, 3H), 3.69-3.62 (m, 1H), 3.60-3.54 (m, 1H), 3.50-3.45 (m, 1H), 3.50-3.45 (m, 1H), 3.40 (t, 1H, J=9.0 Hz), 3.03-3.00 (m, 1H), 3.01, 2.95 (ABq, 2H, J=14.6 Hz), 2.85 (s, 3H), 2.26-2.19 (m, 1H), 1.92-1.85 (m, 1H), 1.62-1.55 (m, 2H), 1.48 (s, 3H), 1.42 (m, 2H), 0.93 (t, 3H, J=7.0 Hz). MS [EI+] 499 (M+H)+, [EI−] 497 (M−H)+.

Workup

  1. concentrationconcentrated in vacuo
  2. additionThe residue is diluted with 1N HCl
  3. extractionextracted
  4. customdried
  5. concentrationconcentrated
  6. custompurified by LCMS

Sources & evidence

ORD record
ord-a285112229764a98924b85bfb9e39505
Source dataset
uspto-grants-2009_06
Patent number
US07544812B2

Reaction notes

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