Sodium Hydroxide → 2-Methyl-3-(4-{2-[3-methyl-2-oxo-1-(4-trifluoromethyl-benzyl)-imidazolidin-4-yl]-ethoxy}-phenyl)-2-phenoxy-propionic acid

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Reaction Steps

A solution of 2-methyl-3-(4-{2-[3-methyl-2-oxo-1-(4-trifluoromethyl-benzyl)-imidazolidin-4-yl]-ethoxy}-phenyl)-2-phenoxy-propionic acid ethyl ester and 5N NaOH (0.7 mL) in ethanol (6 mL) is refluxed for 1 h, cooled to ambient temperature, and concentrated. The residue is diluted with CH2Cl2, washed, dried, and concentrated to provide the title compound (0.186 g, 100%). 1H NMR (400 MHz, CDCl3): δ 7.54 (d, 2H, J=8.3 Hz), 7.35 (d, 2H, J=8.3 Hz), 7.24-7.17 (m, 4H), 7.00 (t, 1H, J=7.4 Hz), 6.89 (d, 2H, J=7.4 Hz), 6.73 (d, 2H, J=8.3 Hz), 4.45, 4.37 (ABq, 2H, J=15.7 Hz), 3.96 (t, 2H, J=5.5 Hz), 3.68-3.62 (m, 1H), 3.38 (t, 1H, J=8.3 Hz), 3.32, 3.10 (ABq, 2H, J=12.9 Hz), 3.00 (t, 1H, J=8.3 Hz), 2.84 (s, 3H), 2.27-2.19 (m, 1H), 1.92-1.85 (m, 1H), 1.39 (s, 3H). MS [EI+] 557 (M+H)+, [EI−] 555 (M−H)+.

Provenance & Evidence