HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 10311939, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-Methyl-3-(4-{2-[3-methyl-2-oxo-1-(3-trifluoromethyl-benzyl)-imidazolidin-4-yl]-ethoxy}-phenyl)-2-phenoxy-propionic acid ethyl ester | HCID 10239982 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 10311939 | HCID 10311939 | 30.3% |
Reaction Steps
To a solution of the esters obtained from Step A (270 mg) in absolute ethanol (4.5 ml) is added 5N NaOH (1.9 ml, 9.5 mmol), and the mixture stirred for 20 hours at ambient temperature. The mixture is poured into 1N HCl, then extracted with ethyl acetate (2×20 ml). The combined ethyl acetate extracts were washed with water, brine, dried (Na2SO4), and concentrated to an oil which is purified is purified by flash chromatography on a Biotage silica cartridge (gradient elution, 3:1 hexanes:ethyl acetate to 1:2 hexanes:ethyl acetate to yield a foam (78 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07544812B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-9902d53b004c4a5da5c88617786dbcc5 |
| Source note | uspto-grants-2009_06 |