Hydrochloric Acid → HCID 10218400, compound

Participants

Reaction Steps

To a solution of the esters obtained from Step A (320 mg) in absolute ethanol (5.5 ml) is added 5N NaOH (2.2 ml, 10.9 mmol), and the mixture stirred for 20 hours at ambient temperature. The mixture is poured into 1N HCl, then extracted with ethyl acetate (2×20 ml). The combined ethyl acetate extracts were washed with water, brine, dried (Na2SO4), and concentrated to an oil which is purified is purified by flash chromatography on a Biotage silica cartridge (gradient elution, 3:1 hexanes:ethyl acetate to 1:2 hexanes:ethyl acetate to yield a foam (180 mg.)

Provenance & Evidence