Potassium Carbonate → HCID 57719025, compound

Participants

Reaction Conditions

Reaction Steps

The crude 1-(3,4-dimethyl-benzyl)-4-[3-(4-hydroxy-phenyl)-propyl]-5-methyl-3-propyl-1,3-dihydro-imidazol-2-one (0.169 g) was combined with ethyl 2-bromoisobutyrate (0.366 g, 1.87 mmol), MgSO4 (0.043 g, 0.357 mmol) and 325 mesh K2CO3 (0.197 g, 1.43 mmol) in ethanol (8 mL) and heated a 75° C. for 16 h under N2. The reaction was cooled and the solvent removed in vacuo. The residue was acidified with 1 N HCl (10 mL) and extracted with EtOAc and water. The organic layer was dried (MgSO4), and the solvent removed in vacuo to afford crude product that was purified by flash chromatography using 2:1 to hexanes:acetone to afford 0.124 g (69%) 2-(4-{3-[1-(3,4-dimethyl-benzyl)-5-methyl-2-oxo-3-propyl-2,3-dihydro-1H-imidazol-4-yl]-propyl}-phenoxy)-2-methyl-propionic acid ethyl ester. MS (ES+) Calc'd for C31H43N2O4 (M+1) 507. Found m/z 507 (100%). 1H NMR.

Provenance & Evidence