Hydrochloric Acid → HCID 57719026, compound

Participants

Reaction Steps

A solution of 2-(4-{3-[1-(3,4-dimethyl-benzyl)-5-methyl-2-oxo-3-propyl-2,3-dihydro-1H-imidazol-4-yl]-propyl}-phenoxy)-2-methyl-propionic acid ethyl ester (0.124 g, 0.244 mmol) in EtOH (10 mL) was treated with aqueous 5 N NaOH (0.5 mL) and heated to reflux under N2 for 1 h. The reaction was cooled and the solvent removed in vacuo to give a residue that was acidified with aqueous 1 N HCl. The mixture was extracted with Et2O and water, the organic layer dried (MgSO4), and the solvent removed in vacuo to afford 0.104 g (89%) 2-(4-{3-[1-(3,4-dimethyl-benzyl)-5-methyl-2-oxo-3-propyl-2,3-dihydro-1H-imidazol-4-yl]-propyl}-phenoxy)-2-methyl-propionic acid. HRMS (ES+) m/z exact mass calcd for C29H39N2O4 [M+1] 479.2910, found 479.2917. 1H NMR.

Provenance & Evidence