Acetic Acid → HCID 57718984, compound

Participants

Reaction Conditions

Reaction Steps

A −78° C. solution of 2-(4-trifluoromethyl-phenoxy)-propionic acid ethyl ester (10.0 g, 38.1 mmol) in THF (80 mL) was transferred via cannula to a −78° C. solution of 1.5 M LDA-THF complex (45.8 mL, 68.7 mmol) in THF (80 mL). The resultant mixture was stirred for 5 minutes at −78° C. and then 3-benzyloxybenzaldehyde (7.3 g, 34.4 mmol) was added in one portion and the reaction mixture stirred at −78° C. for 5 minutes and was then was quenched with a −78° C. THF solution of acetic acid (6.82 g, 113.5 mmol). The reaction mixture was diluted with aqueous saturated NH4Cl and extracted with Et2O. The organic layer was dried (Na2SO4) and the solvent removed in vacuo to afford 19.84 g of crude product that was purified by flash chromatography using 8:1 then 4:1 hexanes:acetone to afford 7.88 g (44%) 3-(3-benzyloxy-phenyl)-3-hydroxy-2-methyl-2-(4-trifluoromethyl-phenoxy)-propionic acid ethyl ester as a mixture of diasteriomers. Rf=0.55 (1:1 hexanes:acetone). 1NMR.

Provenance & Evidence