Tributylvinyltin → HCID 10311395, compound

Participants

Reaction Conditions

Reaction Steps

2-(4-{3-[1-(4-tert-Butyl-benzyl)-3-methyl-2-oxo-imidazolidin-4-yl]-propyl}-2-iodo-phenoxy)-2-methyl-propionic acid methyl ester (0.264 g, 0.435 mmole) and tributyl(vinyl) tin (0.207 g, 0.652 mmole) were mixed in toluene (4.0 mL). After bubbled with nitrogen for 15 minutes, tetrakis(triphenylphosphine) palladium(0) (0.050 g, 0.043 mmole) was added. The reaction was heated at 80° C. overnight. The solvent was removed on rota-vapor, and the crude product was purified by column chromatography (silica gel, gradient elution 0-30% acetone in hexane) to provide a colorless oil (0.158 g, 71%). Mass [EI+] 507 (M+H)+.

Provenance & Evidence