1,2-Dibromoethane → 1-(2-BroMoethoxy)-4(trifluoroMethyl)benzene

Participants

Reaction Steps

A suspension of 5.0 g of 4-hydroxybenzotrifluoride, 17.4 g of 1,2-dibromoethane and 2.6 g potassium carbonate in acetone (100 ml) was heated under reflux for 3 days. The reaction solution was diluted with water and ethyl acetate. The organic layer was washed with saturated aqueous sodium hydrogen carbonate and saturated ammonium chloride (×2), dried over anhydrous sodium sulfate and concentrated. The residue was purified by silica gel column chromatography to give 1.78 g of the title compound as a colorless oil.

Provenance & Evidence