Propargyl alcohol → HCID 22926886, compound

Participants

Reaction Steps

550 mg of Ethyl 2-isopropoxy-3-(3-[(trifluoromethyl)sulfonyl]oxyphenyl)propanoate was dissolved in 5 ml of N,N-dimethylformamide, and 160 mg of propargyl alcohol, 13 mg of copper iodide, 83 mg of tetrakis(triphenylphosphine)palladium and 1 ml of triethylamine were added. After stirring was continued at 50° C. for 4 hours under nitrogen atmosphere, the reaction mixture was diluted with ethyl acetate and washed with water and 1N hydrochloric acid. The organic layer was dried over anhydrous magnesium sulfate, filtered, and the solvent was distilled off. Then, the residue was purified by silica gel column chromatography, to give 184 mg of the title compound in the 4:1→2:1 hexane-ethyl acetate fraction.

Provenance & Evidence