Phenyl isocyanate → Dimethyl 2-(3-{[(anilinocarbonyl)oxy]methyl}benzyl)malonate

HRID 1985337Notes

Reaction equation

[OH:1][CH2:2][C:3]1[CH:4]=[C:5]([CH:16]=[CH:17][CH:18]=1)[CH2:6][CH:7]([C:12]([O:14][CH3:15])=[O:13])[C:8]([O:10][CH3:11])=[O:9].[C:19]1([N:25]=[C:26]=[O:27])[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[NH:25]([C:26]([O:1][CH2:2][C:3]1[CH:4]=[C:5]([CH:16]=[CH:17][CH:18]=1)[CH2:6][CH:7]([C:8]([O:10][CH3:11])=[O:9])[C:12]([O:14][CH3:15])=[O:13])=[O:27])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

Reactant 2

HCID 7672Phenyl isocyanate

HCID 22926882Dimethyl 2-[3-(hydroxymethyl)benzyl]malonate

Product 1

HCID 57719975Dimethyl 2-(3-{[(anilinocarbonyl)oxy]methyl}benzyl)malonate

Procedure

Using dimethyl 2-[3-(hydroxymethyl)benzyl]malonate and phenylisocyanate, the title compound was obtained in the same manner as described in Example 192b).

Sources & evidence

ORD record: ord-67156f1fafa344e2b9622675411e6f14
Source dataset: uspto-grants-2009_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07544835B2

Reaction notes

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