4-Methylphenyl isocyanate → Dimethyl 2-(3-{[(4-toluidinocarbonyl)oxy]methyl}benzyl)malonate

HRID 1985338Notes

Reaction equation

HRID 1985338 reaction equation
[OH:1][CH2:2][C:3]1[CH:4]=[C:5]([CH:16]=[CH:17][CH:18]=1)[CH2:6][CH:7]([C:12]([O:14][CH3:15])=[O:13])[C:8]([O:10][CH3:11])=[O:9].[C:19]1([CH3:28])[CH:24]=[CH:23][C:22]([N:25]=[C:26]=[O:27])=[CH:21][CH:20]=1>>[C:19]1([CH3:28])[CH:24]=[CH:23][C:22]([NH:25][C:26]([O:1][CH2:2][C:3]2[CH:4]=[C:5]([CH:16]=[CH:17][CH:18]=2)[CH2:6][CH:7]([C:8]([O:10][CH3:11])=[O:9])[C:12]([O:14][CH3:15])=[O:13])=[O:27])=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 693254-Methylphenyl isocyanateHCID 22926882Dimethyl 2-[3-(hydroxymethyl)benzyl]malonate

Product 1

HCID 57719608Dimethyl 2-(3-{[(4-toluidinocarbonyl)oxy]methyl}benzyl)malonate

Procedure

Using dimethyl 2-[3-(hydroxymethyl)benzyl]malonate and p-tolylisocyanate, the title compound was obtained in the same manner as described in Example 192b).

Sources & evidence

ORD record
ord-51fa1b9e198d4c75af92ef0fe0a3e581
Source dataset
uspto-grants-2009_06
Patent number
US07544835B2

Reaction notes

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