1-Isocyanato-4-methoxybenzene → Dimethyl 2-[3-({[(4-methoxyanilino)carbonyl]oxy}methyl)benzyl]malonate

HRID 1985339Notes

Reaction equation

HRID 1985339 reaction equation
[OH:1][CH2:2][C:3]1[CH:4]=[C:5]([CH:16]=[CH:17][CH:18]=1)[CH2:6][CH:7]([C:12]([O:14][CH3:15])=[O:13])[C:8]([O:10][CH3:11])=[O:9].[CH3:19][O:20][C:21]1[CH:26]=[CH:25][C:24]([N:27]=[C:28]=[O:29])=[CH:23][CH:22]=1>>[CH3:19][O:20][C:21]1[CH:26]=[CH:25][C:24]([NH:27][C:28]([O:1][CH2:2][C:3]2[CH:4]=[C:5]([CH:16]=[CH:17][CH:18]=2)[CH2:6][CH:7]([C:8]([O:10][CH3:11])=[O:9])[C:12]([O:14][CH3:15])=[O:13])=[O:29])=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 794431-Isocyanato-4-methoxybenzeneHCID 22926882Dimethyl 2-[3-(hydroxymethyl)benzyl]malonate

Product 1

HCID 57719678Dimethyl 2-[3-({[(4-methoxyanilino)carbonyl]oxy}methyl)benzyl]malonate

Procedure

Using dimethyl 2-[3-(hydroxymethyl)benzyl]malonate and 4-methoxyphenylisocyanate, the title compound was obtained in the same manner as described in Example 192b).

Sources & evidence

ORD record
ord-cf701b43fab34e1dbe51605f2af75ab4
Source dataset
uspto-grants-2009_06
Patent number
US07544835B2

Reaction notes

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