2,4-Difluorophenyl isocyanate → Dimethyl 2-[3-({[(2,4-difluoroanilino)carbonyl]oxy}methyl)benzyl]malonate

HRID 1985344Notes

Reaction equation

HRID 1985344 reaction equation
[OH:1][CH2:2][C:3]1[CH:4]=[C:5]([CH:16]=[CH:17][CH:18]=1)[CH2:6][CH:7]([C:12]([O:14][CH3:15])=[O:13])[C:8]([O:10][CH3:11])=[O:9].[F:19][C:20]1[CH:25]=[C:24]([F:26])[CH:23]=[CH:22][C:21]=1[N:27]=[C:28]=[O:29]>>[F:19][C:20]1[CH:25]=[C:24]([F:26])[CH:23]=[CH:22][C:21]=1[NH:27][C:28]([O:1][CH2:2][C:3]1[CH:4]=[C:5]([CH:16]=[CH:17][CH:18]=1)[CH2:6][CH:7]([C:8]([O:10][CH3:11])=[O:9])[C:12]([O:14][CH3:15])=[O:13])=[O:29]

Participants

3

Reactant 2

HCID 5932582,4-Difluorophenyl isocyanateHCID 22926882Dimethyl 2-[3-(hydroxymethyl)benzyl]malonate

Product 1

HCID 57719456Dimethyl 2-[3-({[(2,4-difluoroanilino)carbonyl]oxy}methyl)benzyl]malonate

Procedure

Using dimethyl 2-[3-(hydroxymethyl)benzyl]malonate and 2,4-difluorophenylisocyanate, the title compound was obtained in the same manner as described in Example 192b).

Sources & evidence

ORD record
ord-494dc43dd3a747dcbfbb3c6f4c8acf76
Source dataset
uspto-grants-2009_06
Patent number
US07544835B2

Reaction notes

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