Phenyl isocyanate → Dimethyl 2-(3-{2-[(anilinocarbonyl)oxy]ethyl}benzyl)malonate

HRID 1985347Notes

Reaction equation

[OH:1][CH2:2][CH2:3][C:4]1[CH:5]=[C:6]([CH:17]=[CH:18][CH:19]=1)[CH2:7][CH:8]([C:13]([O:15][CH3:16])=[O:14])[C:9]([O:11][CH3:12])=[O:10].[C:20]1([N:26]=[C:27]=[O:28])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[NH:26]([C:27]([O:1][CH2:2][CH2:3][C:4]1[CH:5]=[C:6]([CH:17]=[CH:18][CH:19]=1)[CH2:7][CH:8]([C:9]([O:11][CH3:12])=[O:10])[C:13]([O:15][CH3:16])=[O:14])=[O:28])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

Reactant 2

HCID 7672Phenyl isocyanate

HCID 22926790Dimethyl 2-[3-(2-hydroxyethyl)benzyl]malonate

Product 1

HCID 57719873Dimethyl 2-(3-{2-[(anilinocarbonyl)oxy]ethyl}benzyl)malonate

Procedure

Using dimethyl 2-[3-(2-hydroxyethyl)benzyl]malonate and phenylisocyanate, the title compound was obtained in the same manner as described in Example 192b).

Sources & evidence

ORD record: ord-392af452d43945daad95c76d800a09f0
Source dataset: uspto-grants-2009_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07544835B2

Reaction notes

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