1-Isocyanato-4-methoxybenzene → Dimethyl 2-(3-{2-[(4-methoxyanilinocarbonyl)-oxy]ethyl}benzyl)malonate

HRID 1985349Notes

Reaction equation

HRID 1985349 reaction equation
[OH:1][CH2:2][CH2:3][C:4]1[CH:5]=[C:6]([CH:17]=[CH:18][CH:19]=1)[CH2:7][CH:8]([C:13]([O:15][CH3:16])=[O:14])[C:9]([O:11][CH3:12])=[O:10].[CH3:20][O:21][C:22]1[CH:27]=[CH:26][C:25]([N:28]=[C:29]=[O:30])=[CH:24][CH:23]=1>>[CH3:20][O:21][C:22]1[CH:27]=[CH:26][C:25]([NH:28][C:29]([O:1][CH2:2][CH2:3][C:4]2[CH:5]=[C:6]([CH:17]=[CH:18][CH:19]=2)[CH2:7][CH:8]([C:9]([O:11][CH3:12])=[O:10])[C:13]([O:15][CH3:16])=[O:14])=[O:30])=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 794431-Isocyanato-4-methoxybenzeneHCID 22926790Dimethyl 2-[3-(2-hydroxyethyl)benzyl]malonate

Product 1

HCID 57719976Dimethyl 2-(3-{2-[(4-methoxyanilinocarbonyl)-oxy]ethyl}benzyl)malonate

Procedure

Using dimethyl 2-[3-(2-hydroxyethyl)benzyl]malonate and 4-methoxyphenylisocyanate, the title compound was obtained in the same manner as described in Example 192b).

Sources & evidence

ORD record
ord-33e0eda25a26483ea0084d9e7ba80ac6
Source dataset
uspto-grants-2009_06
Patent number
US07544835B2

Reaction notes

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