3-Methoxyphenyl isocyanate → Dimethyl 2-(3-{2-[(3-methoxyanilinocarbonyl)-oxy]ethyl}benzyl)malonate

HRID 1985350Notes

Reaction equation

HRID 1985350 reaction equation
[OH:1][CH2:2][CH2:3][C:4]1[CH:5]=[C:6]([CH:17]=[CH:18][CH:19]=1)[CH2:7][CH:8]([C:13]([O:15][CH3:16])=[O:14])[C:9]([O:11][CH3:12])=[O:10].[CH3:20][O:21][C:22]1[CH:23]=[C:24]([N:28]=[C:29]=[O:30])[CH:25]=[CH:26][CH:27]=1>>[CH3:20][O:21][C:22]1[CH:23]=[C:24]([CH:25]=[CH:26][CH:27]=1)[NH:28][C:29]([O:1][CH2:2][CH2:3][C:4]1[CH:5]=[C:6]([CH:17]=[CH:18][CH:19]=1)[CH2:7][CH:8]([C:9]([O:11][CH3:12])=[O:10])[C:13]([O:15][CH3:16])=[O:14])=[O:30]

Participants

3

Reactant 2

HCID 878433-Methoxyphenyl isocyanateHCID 22926790Dimethyl 2-[3-(2-hydroxyethyl)benzyl]malonate

Product 1

HCID 57719406Dimethyl 2-(3-{2-[(3-methoxyanilinocarbonyl)-oxy]ethyl}benzyl)malonate

Procedure

Using dimethyl 2-[3-(2-hydroxyethyl)benzyl]malonate and 3-methoxyphenylisocyanate, the title compound was obtained in the same manner as described in Example 192b).

Sources & evidence

ORD record
ord-48f8aae33a9d4c7f93b9c6b9f896ec5f
Source dataset
uspto-grants-2009_06
Patent number
US07544835B2

Reaction notes

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