Chlorophenyl isocyanate → Dimethyl 2-(3-{2-[(2-chloroanilinocarbonyl)oxy]ethyl}benzyl)malonate

HRID 1985353Notes

Reaction equation

[OH:1][CH2:2][CH2:3][C:4]1[CH:5]=[C:6]([CH:17]=[CH:18][CH:19]=1)[CH2:7][CH:8]([C:13]([O:15][CH3:16])=[O:14])[C:9]([O:11][CH3:12])=[O:10].[Cl:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[N:27]=[C:28]=[O:29]>>[Cl:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[NH:27][C:28]([O:1][CH2:2][CH2:3][C:4]1[CH:5]=[C:6]([CH:17]=[CH:18][CH:19]=1)[CH2:7][CH:8]([C:9]([O:11][CH3:12])=[O:10])[C:13]([O:15][CH3:16])=[O:14])=[O:29]

Participants

Reactant 2

HCID 76833Chlorophenyl isocyanate

HCID 22926790Dimethyl 2-[3-(2-hydroxyethyl)benzyl]malonate

Product 1

HCID 57719886Dimethyl 2-(3-{2-[(2-chloroanilinocarbonyl)oxy]ethyl}benzyl)malonate

Procedure

Using dimethyl 2-[3-(2-hydroxyethyl)benzyl]malonate and 2-chlorophenylisocyanate, the title compound was obtained in the same manner as described in Example 192b).

Sources & evidence

ORD record: ord-7e555e3239f0478ba8022717db99889a
Source dataset: uspto-grants-2009_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07544835B2

Reaction notes

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