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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1985379Generated: October 26, 2026

2,4-Difluorophenyl isocyanate → Dimethyl 2-[3-({[(2,4-difluoroanilino)carbonyl]-oxy}methyl)-4-ethoxybenzyl]malonate

https://huagongshe.com/reaction/1985379

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,4-Difluorophenyl isocyanateHCID 593258—
ReactantDimethyl 2-[4-ethoxy-3-(hydroxymethyl)benzyl]malonateHCID 22926717—
ProductDimethyl 2-[3-({[(2,4-difluoroanilino)carbonyl]-oxy}methyl)-4-ethoxybenzyl]malonateHCID 57719929—

Reaction Steps

Using dimethyl 2-[4-ethoxy-3-(hydroxymethyl)benzyl]-malonate and 2,4-difluorophenylisocyanate, the title compound was obtained in the same manner as described in Example 192b)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07544835B2
Source datasetuspto-grants-2009_06
ORD IDord-7e1a2d6428b04c9e88d617fc19cbdfe3
Source noteuspto-grants-2009_06