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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1985380Generated: October 26, 2026

4-(Trifluoromethyl)phenyl isocyanate → Dimethyl 2-{4-ethoxy-3-[({[4-(trifluoromethyl)anilino]carbonyl}oxy)-methyl]benzyl}malonate

https://huagongshe.com/reaction/1985380

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Trifluoromethyl)phenyl isocyanateHCID 73768—
ReactantDimethyl 2-[4-ethoxy-3-(hydroxymethyl)benzyl]malonateHCID 22926717—
ProductDimethyl 2-{4-ethoxy-3-[({[4-(trifluoromethyl)anilino]carbonyl}oxy)-methyl]benzyl}malonateHCID 57719836—

Reaction Steps

Using dimethyl 2-[4-ethoxy-3-(hydroxymethyl)benzyl]-malonate and α,α,α-trifluoro-p-tolylisocyanate, the title compound was obtained in the same manner as described in Example 192b).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07544835B2
Source datasetuspto-grants-2009_06
ORD IDord-603461bb183a487781c9b32243399b76
Source noteuspto-grants-2009_06