Hydrochloric Acid → HCID 57719936, compound

Participants

Reaction Steps

220 mg of 3-{3-[3-(2,4-Dichlorophenoxy)-2(S)-hydroxypropoxy]phenyl}-2(S)-isopropoxypropanoic acid ethyl ester was dissolved in 4 ml of ethanol, followed by adding 1 ml of 1N sodium hydroxide. After standing as it was at room temperature for 4 hours, the solution was neutralized with 1N hydrochloric acid and extracted with ethylacetate. The organic layer was dried over anhydrous magnesium sulfate, and the solvent was evaporated. The residue was purified by silica gel column chromatography, to give 200 mg of the title compound as a colorless oil in the 3:2→2:3 hexane-ethyl acetate fraction.

Provenance & Evidence