Tetrabutylammonium Fluoride → HCID 22926767, compound

Participants

Reaction Steps

1.2 g of Ethyl 3-[3-(t-butyldimethylsilanyloxymethyl)-4-fluorophenyl]-2-isopropoxypropionate was dissolved in 15 ml of tetrahydrofuran, and 3.3 ml of 1.0M tetrabutyl ammonium fluoride in tetrahydrofuran was added. The mixture was stirred at room temperature for 2 hours. The reaction solution was diluted with water and extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, and evaporated. The residue was subjected to silica gel column chromatography (30% ethyl acetate-hexane), to give 1.0 g of the title compound.

Provenance & Evidence