HCID 59732028, compound → HCID 59732022, compound

HRID 1985464Notes

Reaction equation

[C:1]([O:5][C:6](=[O:29])[NH:7][C:8]1[CH:9]=[CH:10][C:11]2[CH2:17][C@@H:16]([NH2:18])[C:15](=[O:19])[N:14]([CH2:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[CH2:13][C:12]=2[C:27]=1[CH3:28])([CH3:4])([CH3:3])[CH3:2].C(N1C(=O)[C@H](N[C:46]([N:48]2[CH2:53][CH2:52][CH:51]([N:54]3[CH2:63][C:62]4[C:57](=[CH:58][CH:59]=[CH:60][CH:61]=4)[NH:56][C:55]3=[O:64])[CH2:50][CH2:49]2)=[O:47])CC2C=C(C)C(NC(=O)OC(C)(C)C)=CC=2C1)C1C=CC=CC=1>>[CH2:20]([N:14]1[C:15](=[O:19])[C@H:16]([NH:18][C:46]([N:48]2[CH2:53][CH2:52][CH:51]([N:54]3[CH2:63][C:62]4[C:57](=[CH:58][CH:59]=[CH:60][CH:61]=4)[NH:56][C:55]3=[O:64])[CH2:50][CH2:49]2)=[O:47])[CH2:17][C:11]2[CH:10]=[CH:9][C:8]([NH:7][C:6](=[O:29])[O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[C:27]([CH3:28])[C:12]=2[CH2:13]1)[C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1

Participants

Reactant 2

HCID 59732028HCID 59732028, compound

HCID 59732044HCID 59732044, compound

Product 1

HCID 59732022HCID 59732022, compoundYield 94%

Procedure

(R)-tert-Butyl-4-amino-2-benzyl-9-methyl-3-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepin-8-ylcarbamate was reacted in a manner analogous to the preparation of (R)-tert-butyl 2-benzyl-7-methyl-3-oxo-4-(4-(2-oxo-1,2-dihydroquinazolin-3(4H)-yl)piperidine-1-carboxamido)-2,3,4,5-tetrahydro-1H-benzo[c]azepin-8-ylcarbamate. Title compound was obtained as off-white solid in 94% yield.

Sources & evidence

ORD record: ord-b9a48cd6fe384112b6d8cc70d92768aa
Source dataset: uspto-grants-2009_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07544680B2

Reaction notes

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