HuagongsheHuagongshe Chemistry Print Report · For research reference only
alpha-Bromo-2-nitrotoluene → tert-Butyl 4-(1-methoxy-3-(2-nitrophenyl)-1-oxopropan-2-yl)piperazine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | alpha-Bromo-2-nitrotoluene | HCID 77569 | — |
| Reactant | Tert-butyl 4-(2-methoxy-2-oxoethyl)piperazine-1-carboxylate | HCID 46785870 | — |
| Reactant | Tert-butyl 4-(1-methoxy-3-(2-nitrophenyl)-1-oxopropan-2-yl)piperidine-1-carboxylate | HCID 59732041 | — |
| Product | tert-Butyl 4-(1-methoxy-3-(2-nitrophenyl)-1-oxopropan-2-yl)piperazine-1-carboxylate | HCID 59732018 | 51% |
Reaction Steps
tert-Butyl 4-(2-methoxy-2-oxoethyl)piperazine-1-carboxylate (1.0 g, 3.9 mmol) and 2-nitrobenzylbromide (1.0 g, 4.6 mmol) were reacted in a manner analogous to the preparation of tert-butyl 4-(1-methoxy-3-(2-nitrophenyl)-1-oxopropan-2-yl)piperidine-1-carboxylate. Title compound was obtained as amber oil in 51% yield. MS m/e (M+H)+=394.4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07544680B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-b6a8978ffd014ceb8cceddbb14a0313f |
| Source note | uspto-grants-2009_06 |