HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(piperidin-4-yl)-3,4-dihydroquinolin-2(1H)-one → 2-(Piperidin-4-yl)-1,2-dihydroisoquinolin-3(4H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(piperidin-4-yl)-3,4-dihydroquinolin-2(1H)-one | HCID 18321246 | — |
| Reactant | tert-Butyl 4-(3-oxo-3,4-dihydroisoquinolin-2(1H)-yl)piperidine-1-carboxylate | HCID 59731897 | — |
| Product | 2-(Piperidin-4-yl)-1,2-dihydroisoquinolin-3(4H)-one | HCID 59731888 | 96% |
Reaction Steps
tert-Butyl 4-(3-oxo-3,4-dihydroisoquinolin-2(1H)-yl)piperidine-1-carboxylate (730 mg, 2.2 mmol) was reacted in a manner analogous to the preparation of 3-(piperidin-4-yl)-3,4-dihydroquinolin-2(1H)-one. Title compound was obtained as yellow solid in 96% yield. MS m/e (M+H)+=231.4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07544680B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-115a8d676ccc440286912532cdefef8e |
| Source note | uspto-grants-2009_06 |