Trifluoroacetic acid → HCID 68825958, compound

Participants

Reaction Steps

(R)—N-(8-Amino-2-benzyl-7-methyl-3-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-yl)-4-(2-oxo-1,2-dihydroquinazolin-3(4H)-yl)piperidine-1-carboxamide (95 mg, 0.15 mmol) was dissolved in dichloromethane (2 mL). Trifluoroacetic acid (1 mL) was added to the mixture. Reaction stirred at room temperature for 1 hour. Mixture was concentrated in vacuo. Residue was purified by preparatory HPLC. Solvent was lyophilized from the proper fractions. Title compound was obtained as white solid in 64% yield. MS m/e (M+H)+=553.

Provenance & Evidence