Dichloromethane → 2-(4-(4-(chloromethyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)piperidin-1-yl)-5-ethylpyrimidine

HRID 198556Notes

Reaction equation

HRID 198556 reaction equation
[CH2:1]([CH3:2])[c:3]1[cH:4][n:5][c:6]([N:9]2[CH2:10][CH2:11][CH:12]([n:15]3[n:16][cH:17][c:18]([CH2:24][OH:25])[c:19]3[C:20]([F:21])([F:22])[F:23])[CH2:13][CH2:14]2)[n:7][cH:8]1.[Cl:30][CH2:31][Cl:32].[S:26]([Cl:27])([Cl:28])=[O:29]>>[CH2:1]([CH3:2])[c:3]1[cH:4][n:5][c:6]([N:9]2[CH2:10][CH2:11][CH:12]([n:15]3[n:16][cH:17][c:18]([CH2:24][Cl:28])[c:19]3[C:20]([F:21])([F:22])[F:23])[CH2:13][CH2:14]2)[n:7][cH:8]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 24386Thionyl ChlorideHCID 57708404(1-(1-(5-Ethylpyrimidin-2-yl)piperidin-4-yl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanol

Product 1

HCID 577083712-(4-(4-(chloromethyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)piperidin-1-yl)-5-ethylpyrimidine

Sources & evidence

ORD record
ord-0633975f01ee4572a224b4df897c346c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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