Propargyl bromide → tert-Butyl 4-(prop-2-yn-1-yl)piperazine-1-carboxylate

Participants

Reaction Conditions

Reaction Steps

To the degassed solution of piperazine-1-carboxylic acid tert-butyl ester (1.0 g, 5.37 mmol) in acetonitrile (10 ml) were added Na2CO3 (1.708 g, 16.11 mmol) and mixture was stirred for 20 min. The suspension was heated to 50° C. and 3-bromo-propyne (0.9 mL, 8.055 mmol) was added. The solvent was evaporated and the residue was extracted with Et-Ac and water (2×50 mL). Organic layer was washed with NaCl and NaHCO3 (2×50 ml). The organic layer was dried over K2CO3 and evaporated in vacuum yielding (0.70 g) oil title intermediate.

Provenance & Evidence