Propargyl bromide → tert-Butyl 4-(prop-2-yn-1-yl)piperazine-1-carboxylate

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Reaction Conditions

Reaction Steps

To the degassed solution of piperazine-1-carboxylic acid tert-butyl ester (0.5 g, 2.69 mmol) in acetonitrile (5 mL) was added Na2CO3 (0.854 g, 8.05 mmol) and mixture was stirred for 20 min. The suspension was heated to 50° C. and 3-bromo-propyne (448.65 μl, 4.03 mmol) was added. The solvent was evaporated and the residue was extracted with EtOAc and water. Organic layer was washed with NaCl and NaHCO3 (2×20 ml), dried over K2CO3 and evaporated in vacuum yielding 0.45 g of the title product as yellowish oil.

Provenance & Evidence