HCID 1531802, compound → HCID 57720100, compound

HRID 1985626Notes

Reaction equation

HRID 1985626 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:15](=[O:16])[C:14]2[C:9]3=[C:10]([CH2:17][CH2:18][CH2:19][N:8]3[CH:7]=1)[CH:11]=[CH:12][CH:13]=2)=[O:5])[CH3:2].OS(O)(=O)=O.[N+:25]([O-])([OH:27])=[O:26]>>[CH2:1]([O:3][C:4]([C:6]1[C:15](=[O:16])[C:14]2[C:9]3=[C:10]([CH2:17][CH2:18][CH2:19][N:8]3[CH:7]=1)[CH:11]=[CH:12][C:13]=2[N+:25]([O-:27])=[O:26])=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 1531802HCID 1531802, compoundHCID 71777668Sulfuric acid, mixt. with nitric acid

Product 1

HCID 57720100HCID 57720100, compoundYield 95%

Conditions

Temperature
0 °C

Procedure

1-Oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid ethyl ester (1.0 g) was placed in round bottom flask and to that, mixture of H2SO4/HNO3 (1:1) was added and stirred for 3 hours at 0° C. The reaction mixture was poured on ice and precipitate was filtered off affording 900 mg of title product (LC/MS: 95%).

Workup

  1. additionwas added
  2. additionThe reaction mixture was poured on ice and precipitate
  3. filtrationwas filtered off

Sources & evidence

ORD record
ord-954a16f0c0cf480884bf88843454c761
Source dataset
uspto-grants-2009_06
Patent number
US07547679B2

Reaction notes

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