HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1985630Generated: November 1, 2026
Sodium Hydroxide → 1-Ethyl-6-iodo-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid
https://huagongshe.com/reaction/1985630
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 1-ethyl-6-iodo-4-oxo-1,4-dihydroquinoline-3-carboxylate | HCID 57720090 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-Ethyl-6-iodo-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid | HCID 17980487 | 106.4% |
Reaction Steps
1,4-Dihydro-1-ethyl-6-iodo-4-oxo-quinoline-3-carboxylic acid ethyl ester (7.5 g, 0.02 mol) was suspended in THF (75 mL), NaOH (2 equiv.) solution in water (75 mL) was added and the mixture was stirred at 80° C. for 24 hours. After THF was evaporated, the solution was acidified to pH 5 using HCl. The obtained precipitate was filtrated off and dried under reduced pressure yielding the title compound (7.3 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07547679B2 |
|---|
| Source dataset | uspto-grants-2009_06 |
|---|
| ORD ID | ord-9cd744ffd07e4e70842c3402eec267e1 |
|---|
| Source note | uspto-grants-2009_06 |
|---|
